Lowered testosterone levels may have a number of effects within men. The most commonly cited effects are sexual dysfunction issues, such as impotence. This may be noted so often because it is often easy to tell if a man has become impotent.
This disorder may affect the sex life that a man has with his spouse. And this may cause deleterious effects in a marriage. Many medicines have been created to address this issue. But it still does affect men in various ways all over the world.
Other side effects of undergoing andropause are those that are likely psychological in origin. Men may experience depression and anxiety when they begin to lose their overall testosterone level.
They may feel less confident in themselves, which can further add to existing psychological problems. These may also be accompanied by physiological disorders, such as weight gain and insomnia.
Treatments for Andropause
One way to reduce the effects of andropause may be to initiate a testosterone replacement treatment (TRT) program. The main concept of a TRT program is to give men a synthetic form of testosterone. And to restore their levels back to normal.
One such TRT substance commonly used is testosterone undecanoate. Many prefer to prescribe Andriol because it can be taken orally instead of requiring regular injections. The synthetic testosterone is also not as dangerous for liver function, which means that it won’t cause as many side effects.
Restandol, Andriol or Undestor Testocaps is the trade name for testosterone undecanoate. Which is an orally-active form of the anabolic steroid testosterone. Developed by the pharmaceutical company Organon.
It is usually prescribed to men going through andropause (male menopause). Which is characterized by low natural testosterone levels late in life.
Lower production of the male hormone testosterone (androgen) can lead to a number of problems. Such as low libido, weakness and fatigue due to decline in physical energy. Also depression, loss of muscle mass, high body fat and brittle bones.
Restandol Testocaps was introduced in 2003 by Organon, which redesigned their original andriol product. Organon’s original andriol product had to be kept in freezing conditions, preferably in a refrigerator, and had a short shelf-life of only 3 months.
The company decided to make improvements on this drug, and that’s how the new Testocaps came about. Undestor Testocaps can be kept at room temperature and carries a shelf-life of approximately 3 years.
This version of testosterone is based in oil, and it comes in an oval, soft gelatin capsule. The drug, though not yet approved in the United States, has become a very common and popular means of treating low testosterone, or Andropause.
Testosterone Undecanoate enters the body as a fat through the lymphatic system. The testosterone hormone is attached to the large undecanoate ester and occurs in 40 mg strength.
Although the drug carries 40 mg potency, the mode of administration and absorption inside the body means that only 7 percent of the active testosterone is absorbed.
It is worth noting that testosterone undecanoate is not a C17 alpha-alkylated medication (17-aa alteration which allows oral steroids to pass through the liver and into the body without being broken down), which means the drug does not survive the first pass through the liver.
This trait is extremely appealing, particularly when it comes to treating Andropause, since it means patients don’t have to deal with the risk of hepatotoxicity.
Although testosterone undecanoate carries a rather low bioavailability (due to low absorption rate), the drug is made up of testosterone – which means it carries significant anabolic and androgenic properties.
It also carries all traits associated with testosterone hormones, and may provide performance enhancing benefits for bodybuilders.
Testosterone Undecanoate Benefits
Testosterone Undecanoate may seem like a perfect oral testosterone product on paper – clean, safe and worlds apart from those crude oral testosterone derivatives. Unfortunately, only small amounts of the drug are absorbed through the lymphatic system when ingested.
This contributes to low bioavailability, which means its effects are extremely mild. So using testosterone undecanoate alone will not lead to any significant gains in mass or strength.
The drug is actually a very poor choice for typical performance enhancing practices. However, when stacked together with other stronger anabolic androgenic steroids, it can provide positive effects on muscle mass, recovery, workouts, and libido.
This is because it is still a testosterone hormone and will provide all the benefits associated with the male hormone. This includes losing excess body fat, gaining muscle, gaining strength, and other man-like effects.
Testosterone undecanoate provides all the benefits associated with testosterone hormones supplementation, albeit in a much smaller scale. It is particularly helpful when it comes to treating low testosterone caused by hypogonadism or andropause.
The body’s failure to produce enough natural testosterone (as a result of these conditions) often causes a decrease in bone density, a decrease in skeletal muscle mass, an increase in fatty tissue deposits, a decrease in libido, erectile dysfunction, depression, fatigue, weakness and general poor state of both physical and mental health and well-being.
By replacing natural testosterone, it helps alleviate or even reverse these symptoms.
Like other testosterone products, Undecanoate enhanced protein synthesis. Protein synthesis is the process that ultimately results in increased muscle mass.
Increased protein synthesis is also a vital mechanism by which testosterone increases skeletal muscle mass. Protein is the primary building block of muscle and bone mass.
By increasing the rate by which cells build proteins,it increases the body’s anabolic atmosphere – which boosts muscle growth, recovery and strength.
Testosterone undecanoate also increases the body’s ability to retain nitrogen which promotes the body’s anabolic atmosphere, as well. Lean muscle tissue consists of 16 percent nitrogen, and optimal nitrogen balance must be maintained to prevent catabolic (muscle wasting) state.
By allowing for enhanced retention and better utilization of the nitrogen in ingested protein, this drug can help bodybuilders and athletes to build body mass.
Testosterone supplementation helps increase red blood cell count. Red blood cells are the pigment responsible for carrying oxygen throughout the circulatory system, from the lungs to the rest of the body, and bringing carbon dioxide waste back the other way.
By increasing red blood cells, andriol leads to an increase in the amount of oxygen that can be delivered to muscle. This, in turn, produces positive effects on recovery, muscular endurance and muscle growth.
Testosterone supplementation may also lead to increased Insulin-Like Growth Factor-1 (IGF-1), a potent naturally-produced peptide hormone that is a vital component for growth hormone to have its positive anabolic effects on muscles, bones, joints, tendons, and ligaments.
The benefits of increased levels of IGF-1 for bodybuilders and athletes are plenty. Firstly, it helps burn excess body fat and build lean muscle mass. IGF-1 also increases the body’s ability to recover from injury.
It enhances the body’s ability to recover after strenuous exercise and its positive effects are felt in nearly every cell within the body. It has also been shown to increase physical and sexual endurance as well as cardiovascular endurance, which could benefit bodybuilders and athletes who regularly undertake cardiovascular exercises.
Although glucocorticoid hormones are essential for our health, high levels of these substances can lead to a catabolic state – which leads to destruction of muscle tissue and fat gain.
Testosterone Undecanoate Side Effects
The drug’s mode of administration and the small amount of testosterone absorbed by the body mean that this dug has little or no negative side effects, particularly for hypogonadism or andropause patients suffering from low testosterone levels.
Nonetheless, abuse of testosterone products like testosterone undecanoate can lead to any number of adverse health effects. These undesirable side effects can include: suppressed natural testosterone production, estrogenic, androgenic, and cardiovascular side effects.
Androgenic side effects include: acne, body hair growth, accelerated hair loss in males that are predisposed to male pattern baldness, and virilization symptoms, such as body hair growth, clitoral enlargement and a deepening of the vocal chords, in women.
Supraphysiological doses of testosterone can cause estrogenic side effects such as gynecomastia and water retention, while high doses of testosterone may cause cardiovascular side effects like high blood pressure and unhealthy cholesterol levels.
Supplementing with anti-estrogenic drugs, cholesterol antioxidant supplements, and following a cholesterol healthy lifestyle may help mitigate some of these undesirable side effects of Testosterone Undecanoate.