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Anavar is the old trade name for the synthetic anabolic steroid Oxandrolone, also known as Oxandrin. Developed and patented in 1964 by the pharmaceutical giant Searle Laboratories, now Pfizer Inc., Oxandrolone is a derivative of the male sex hormone Dihydrotestosterone (or DHT).
The main purpose for this steroid was to stimulate muscle regrowth in patients with disorders that caused involuntary weight loss, such as Grave’s disease. Even today, it is still prescribed as part of the treatment for Grave’s disease, hepatitis as well as HIV and AIDS.
After it was discovered that it had potential for promoting muscle growth, it was used extensively by athletes and bodybuilders off-label.
However, lagging sales as a result of the FDA’s pressure that had tightened its grip on the steroid market in the 1980s saw Searle Laboratories discontinue its manufacture in 1989. The drug, in fact, had vanished from pharmacies in the USA until recently, save for the black market.
The rights to redistribute Oxandrolone were purchased by the biopharmaceutical company Bio-Technology General Corporation, now Savient; and thanks to their efforts and those of generic drug manufacturers the drug is now widely available for treating a variety of conditions including HIV/AIDS related wasting syndrome. It is now marketed under the trade name Anavar.
Oxandrolone consists of DHT hormone, which has been structurally altered. On its chemical structure, an Oxygen atom replaces the 2nd carbon of the first cycloalkaline ring and the methylation at the 17 position.
The C17 alpha alkylation (17aa) enhances the steroid’s anabolic activity as well as bioavailability, allowing it to avoid first pass liver metabolic degradation – which, in turn, allows the drug to be taken orally.
The fact that the 2 carbon is completely replaced by a different atom (Oxygen atom) makes this steroid quite unique among all anabolic steroids. This direct modification is thought to boost its anabolic strength compared to DHT, but it still remains a very mild anabolic steroid, one that could even be used in children.
Once Oxandrolone is ingested it mixes in the blood and is absorbed into the system very quickly. Although other anabolic steroids are also absorbed fast, Anavar is absorbed quickly due to the fact that it has an extremely short half life cycle (about 9 hours).
For this reason, the drug must be taken on a daily basis. A typical dosage of anavar steroid tablets for men ranges from 50 to 80 mg per day for about 5 to 8 weeks, while that for women in can range between 10 to 20 mg per day.
These dosages represent the level at which the steroid is able to deliver noticeable results.
Oxandrolone Benefits for Bodybuilders
Anavar is considered the product of our never-ending quest to create and develop a “perfect” anabolic steroid that is both safe and effective.
This steroid offers probably the best safety profile and side effect-to-benefit ratio, which has seen it become one of the most popular and well known anabolic steroids of all time.
It is extremely gentle and very safe, making it one of the few anabolic steroids that are well tolerated by female bodybuilders and athletes.
The drug can be and is frequently used safely to promote growth and development in children with conditions that inhibit proper hormone production.
Oxandrolone was designed to be an extremely mild anabolic with low androgenic activity. This mild nature of Anavar is often underappreciated, particularly by users with unrealistic expectations.
But there’s no denying the fact that this steroid can prove quite beneficial for bodybuilders wishing to achieve increased athletic performance, strength gain, and lean muscle gain, where the excess water weight gain and possible fat retention/gain is not desired.
Oxandrolone is also one of the best anabolic steroids for use by bodybuilders looking to shed extra body fat and maintain as much lean muscle as possible during a caloric deficit.
It is important to note that while Anavar is mild in nature, the steroid carries massive anabolic properties. In fact, it is 4-6 times stronger than testosterone. This high anabolic power might insinuate that the drug has tremendous bulking potential.
But its muscle building properties are typically effective in a cutting cycle and it is not meant for bulking purposes or increasing body mass.
Due to its anabolic nature, Anavar’s main benefit is of helping preserve the muscles and metabolic activity. It can also be extremely helpful when it comes to direct athletic enhancement.
Anavar can help bodybuilders recover from a hard workout more quickly by reducing the muscle damage that occurs during the session. This allows bodybuilders to work out harder and more frequently without overtraining.
Additionally, Anavar helps bodybuilders increase strength, a key factor in maximizing athleticism. Increased strength translates to speed and power, allowing athletes and bodybuilders to push longer and harder.
By using Anavar, bodybuilders are able to achieve strong muscle tissues that ensure great metabolic activity which, in turn, increases the rate at which the body breaks down excess body fat to produce energy.
It is one of the few true fat burning steroids available. This is one important reason why the drug is mostly used by bodybuilders and athletes in their preparation.
The effectiveness of Oxandrolone stems from its ability to boost nitrogen retention in the muscle, decrease sex hormone-binding globulin (SHBG), and inhibit glucocorticoid hormones.
By increasing the level of nitrogen retention in the muscle, Anavar ensures optimal anabolic atmosphere – which is essential for preserving muscle.
The lower SHBG levels results in more of the free testosterone circulating in the body. This produces powerful anabolic effects and also promotes a free or unbound state of all other circulating anabolic steroids, thereby making the other steroids being used effective for optimal muscle building cycle results.
The inhibition of glucocorticoid hormones by Anavar facilitates growth and maintenance of lean muscle mass, particularly during weight loss or cutting cycle.
Glucocorticoid hormones cause destruction of lean muscle tissue leading to muscle wasting – which is responsible for promoting fat gain.
A number of studies have also shown that Anavar helps increase red blood cell count in the system. This, in turn, promotes athleticism by enhancing muscular endurance.
Some research studies have even indicated that Anavar use can lead to enhanced cardiovascular endurance, which is critical to achieving increased strength and performance.
Because of its mild nature, it is most efficiently stacked with stronger anabolic-androgenic steroids such as Dianabol or Anadrol. When combined with such steroids, bodybuilders can realize faster, more pronounced muscle-building effects; but this may also increase the risk of androgenic buildup.
Anavar Side Effects for Bodybuilders
Although it is a mild steroid, Anavar side effects are still possible. This is particularly true when used in high doses or for a long period of time.
However, just like the steroid itself, the side effects of Oxandrolone are quite mild and can be minimized through proper use of the drug.
In fact, many bodybuilders will find that they experience little or no negative side effects.
Firstly, Anavar doesn’t cause any estrogenic side effects. It doesn’t aromatize, which means it can’t cause water retention or gynecomastia due to increased estrogen levels.
This also means there’s no risk of high blood pressure, which is usually caused by water retention from steroid use.
Although there are no androgenic properties associated with it, hormonal virilization may still occur.
This is characterized by symptoms such as excess body hair growth, baldness, acne, deepening of the vocal cords and clitoral enlargement in women.
The most serious side effect associated with Anavar use is probably increased cholesterol, which could lead to heart disease and other cardiovascular related problems.
The steroid increases LDL or bad cholesterol in the system, while suppressing HDL or good cholesterol.
Because of this, those with any cholesterol issues should try to avoid using Anavar. It is also recommended that bodybuilders supplementing with Anavar eat a diet rich in Omega fatty acids to reduce the potential negative effect of high cholesterol.
Like other anabolic steroids, Anavar suppresses natural testosterone production. But the degree of suppression is much lower compared to that of other steroids.
Furthermore, the low testosterone state caused by Oxandrolone use can be off-set by exogenous testosterone use during supplementation.
Lastly, as a C 17 alpha-alkylated steroid, Anavar can be toxic to the liver. The level of liver hepatotoxicity typically increases with continued use or increase in the dosages.
Nonetheless, this steroid carries probably the lowest hepatotoxicity potential compared with all other anabolic steroids.
This means the risk of liver damage is very low; but it is still imperative that you follow proper procedures when supplementing with this drug or any other steroid out there.
How long does Anavar stay in your system?
Everybody is different, and it also depends on what dosage you have been taking. But most of the experts agree that in 4 weeks it will totally be out of your system.